MovDisordV3, Main, Exploration, bibRecord, 000589

Essential tremor is not associated with cerebellar Purkinje cell loss.

Identifieur interne : 000589 ( Main/Exploration ); précédent : 000588; suivant : 000590

Essential tremor is not associated with cerebellar Purkinje cell loss.

Auteurs : Claire Symanski [États-Unis] ; Holly A. Shill ; Brittany Dugger ; Joseph G. Hentz ; Charles H. Adler ; Sandra A. Jacobson ; Erika Driver-Dunckley ; Thomas G. Beach

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:24532134

English descriptors

KwdEn :
- Aging (pathology), Autopsy, Cell Count, Cerebellum (pathology), Essential Tremor (pathology), Female, Humans, Male, Purkinje Cells (pathology).
MESH :
- pathology : Aging, Cerebellum, Essential Tremor, Purkinje Cells.
- Autopsy, Cell Count, Female, Humans, Male.

Abstract

There has been controversy as to whether there is an underlying neurodegenerative process of the cerebellum in essential tremor (ET). The aim of this study was to examine whether ET is associated with Purkinje cell (PC) loss. Prospectively categorized ET and control subjects who were longitudinally examined in the Arizona Study for Aging and Neurodegenerative Disorders and came to autopsy between 1998 and 2013 underwent standardized neuropathological assessment of the brain. PC linear density of the cerebellar hemisphere was calculated in a blinded manner. There were 56 ET cases and 62 age-matched controls free of dementia and other neurodegenerative disorders included in the study. Mean PC linear density was 3.80 ± 0.81 cells per mm for tremor cases and 3.82 ± 0.91 cells per mm for controls (Δ 0.02; 95% confidence interval [CI]: -0.30-0.34). PC counts were not associated with tremor duration (r = 0.06; 95% CI: -0.21-0.32). These data demonstrate that ET is not associated with cerebellar PC loss.

DOI: 10.1002/mds.25845
PubMed: 24532134

Affiliations:

Le document en format XML

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<author><name sortKey="Driver Dunckley, Erika" sort="Driver Dunckley, Erika" uniqKey="Driver Dunckley E" first="Erika" last="Driver-Dunckley">Erika Driver-Dunckley</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">There has been controversy as to whether there is an underlying neurodegenerative process of the cerebellum in essential tremor (ET). The aim of this study was to examine whether ET is associated with Purkinje cell (PC) loss. Prospectively categorized ET and control subjects who were longitudinally examined in the Arizona Study for Aging and Neurodegenerative Disorders and came to autopsy between 1998 and 2013 underwent standardized neuropathological assessment of the brain. PC linear density of the cerebellar hemisphere was calculated in a blinded manner. There were 56 ET cases and 62 age-matched controls free of dementia and other neurodegenerative disorders included in the study. Mean PC linear density was 3.80 ± 0.81 cells per mm for tremor cases and 3.82 ± 0.91 cells per mm for controls (Δ 0.02; 95% confidence interval [CI]: -0.30-0.34). PC counts were not associated with tremor duration (r = 0.06; 95% CI: -0.21-0.32). These data demonstrate that ET is not associated with cerebellar PC loss.</div>
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<name sortKey="Driver Dunckley, Erika" sort="Driver Dunckley, Erika" uniqKey="Driver Dunckley E" first="Erika" last="Driver-Dunckley">Erika Driver-Dunckley</name>
<name sortKey="Dugger, Brittany" sort="Dugger, Brittany" uniqKey="Dugger B" first="Brittany" last="Dugger">Brittany Dugger</name>
<name sortKey="Hentz, Joseph G" sort="Hentz, Joseph G" uniqKey="Hentz J" first="Joseph G" last="Hentz">Joseph G. Hentz</name>
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<name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name>
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<country name="États-Unis"><region name="Arizona"><name sortKey="Symanski, Claire" sort="Symanski, Claire" uniqKey="Symanski C" first="Claire" last="Symanski">Claire Symanski</name>
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Movement Disorders (revue)

Essential tremor is not associated with cerebellar Purkinje cell loss.

Essential tremor is not associated with cerebellar Purkinje cell loss.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.